Nature (2025)

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

Schoofs H, Daubel N, Schnabellehner S, … Mäkinen T.

Nat Cardiovasc (2025)

Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations

Kraft M, Schoofs H, Petkova M,  … Mäkinen T.

J Exp Med (2023)

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Petkova M, Kraft M, … Mäkinen T.

EMBO J (2021)

Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels

Hernandez-Vasques M, Ulmar MH, … Mäkinen T.

Nat Commun (2020)

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, … Mäkinen T.

Nat Commun (2018)

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Frye M, Taddei A, Dierkes C, Martinez-Corral I, … Mäkinen T

Nat Commun (2018)

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo, K, Mäkinen T.

Cell Rep (2015)

cKit lineage hemogenic endothelium-derived cells contribute to mesenteric lymphatic vessels

Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, … Mäkinen T.

Circ Res (2015)

Non-venous origin of dermal lymphatic vasculature

Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo, K, Mäkinen T.

Dev Cell (2014)

Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during lymphatic valve morphogenesis

Tatin F, Taddei A, … Makinen T.

J Cell Biol (2012)

Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation development and disease

Lutter S, Xie S, Tatin F, Makinen T. 

J Clin Invest (2011)

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice Bazigou E, Lyons OTA, Smith A, Venn GE, Cope C, Brown NA, Makinen T. 

Dev Cell (2009)

Integrin-a9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro A, Sheppard D, Makinen T.

selected reviews

Trends Mol Med (2021)

Homeostatic maintenance of the lymphatic vasculature

Stritt S, Koltowska K, Makinen T

Circ Res (2021)

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Makinen T, Boon LM, Vikkula M, Alitalo K.

Nat Rev Mol Cell Biol (2017)

Vascular heterogeneity and specialization in development and disease

Potente M, Makinen T.